• Charge for 1 Replacement or 1 Transfer Key B for any of the Z Score DLLs after the first 2 Transfer B Keys have been issued, with a maximum of one license transfer per year per licensee.  Prior to ANI issuing a Transfer or Replacement Key B the Licensee must personally email qeeg@appliedneuroscience.com and Certify that the computer has crashed or that the user has removed the DLL from the previous computer and the user must promise not to run the DLL on more than two computers.

  • Purchase LORETA Effective Connectivity to generate Raw and Z Scored LORETA Phase Slope Index bitmaps and tab-delimited-text files.
  • Upgrade your NeuroGuide for BrainMaster (NGBMr) to a NeuroGuide, just pay the difference: NG ($3,395.00)  - NGBMr ($1200.00) = $2,195.00.

  • The NeuroGuide Viewer™ is for for Neurology (Import EEG, Export EEG, Edits, Event Marking, Amplitude Marking, LORETA Time Domain, Event Time Export).

  • Purchase the Surface Effective Connectivity add-on to generate Raw and Z Scored Surface Phase Slope Index bitmaps and tab-delimited-text files.

  • We provide competent and professional QEEG edits and Neurofeedback Protocol Generation.  Dr. Thatcher has evaluated over 20,000 EEG recordings in the last 30 years.

  • Upgrading a NeuroGuide for Collection (NGA), that was purchased before March 15, 2020, to a NeuroGuide is a simple process, you just pay the difference of  NG ($3,395) - NGA ($1000) + the cost of the NC module ($600).
  • The Streamer is a Video Streamer for Neurofeedback. Dock any DVD Player window, or NetFlix, YouTube, hulu or any other Web Service that allows you to watch videos and/or TV show.  Currently there are 2 display options available inside the Streamer that you can link to the Reward:  Brightness or Size.  One must own Surface Z Score Neurofeedback (NF1), LORETA Z Score Neurofeedback (NF2), Surface Cross Frequency Z Score Neurofeedback (NF3) and/or swLORETA Neurofeedback (swNFB) before you can use the ANI Streamer.

  • QEEG Report for Legal Cases contains extra edits, multiple test retest reliability measures and Robert W. Thatcher, Ph.D.'s Expert opinion.

  • QEEG Report by Robert W. Thatcher, Ph.D. plus Neurologist visual review of the EEG traces. We provide an analysis of a recorded QEEG only and no diagnoses.

  • Only Available after the purchase of a full Priced NeuroGuide License.  If you want to purchase a 3rd, 5th, 7th... NeuroGuide License you will need to pay full price.

  • Generate Raw and Z Scored Bit Maps and Tab-delimited-text file for LORETA Phase Shift Duration and Phase Lock Duration.

  • BrainSurfer

    $2,500.00

    BrainSurfer a Brain Computer Interface with 3-D NeuroImaging of Functional Brain Networks, sLORETA of Brodmann Areas & sLORETA of Networks in Real-time and Live Z scores of nodes and connections between nodes as measured by sLORETA Coherence, sLORETA Phase Differences, sLORETA Phase Shift, and sLORETA Phase Lock.

  • NeuroGuide Acquisition (NGA) is a Stand alone EEG acquisition - useful for Satellite Clinics. Includes collection of EEG, import of .ng, .edf & Text files, re-montage, save and print, marking of traces, color and polarity control of traces. No qEEG or editing capability. Also provides EEG biofeedback capability with purchase of NF1, NF2, NF3, swNF and/or Surfer (see NGA + NF1 and/or NF2 and/or NF3 and/or swNF and/or BrainSurfer). Price is $1,500 for each amplifier system.

  • The amplitude of higher EEG frequencies (e.g., beta) are related to the phase of lower EEG frequencies (e.g., theta). Therefore, this is a surface EEG measure of the correlation between the phase and amplitude of the EEG across frequencies and scalp locations, for example delta and beta or theta and alpha-2 or theta and high beta (Gamma), etc. This is a unique and important metric that in part reflects the coupling between the upper cortical layers (I-III that generate beta) and the lower cortical layers (V-VI) that generate delta and theta. This add-on quantifies the coupling and provides a normative database comparison (Z scores) to help link symptoms to dysregulation in the brain.

  • Surface Cross-Frequency Power is an EEG measure of the correlation of power between frequencies and scalp locations, for example delta and beta or theta and alpha-2 or theta and high beta (Gamma), etc.  A given brain region communicates with other brain region over a range of frequencies. Currently available for Raw Values Only.

  • LORETA Cross-Frequency Coherence is anEEG LORETA measure of the Coherence (amplitude independent coupling) between frequencies and the center voxels of 88 different Brodmann areas, for example delta and beta or theta and alpha-2 or theta and high beta (Gamma), etc.  Neurons in a given Brodmann area communicates with other brain regions over a range of frequencies.  This add-on quantifies the coupling and provides a normative database comparison (Z scores) to help link symptoms to dysregulation in the brain.

  • Surface Cross-Frequency Coherence is an EEG measure of the Coherence (amplitude independent coupling) between frequencies and scalp locations, for example delta & beta or theta & alpha-2 or theta & high beta (Gamma), etc.  A given brain region communicates with other brain regions over a range of frequencies.  This add-on quantifies the coupling and provides a normative database comparison (Z scores) to help link symptoms to dysregulation in the brain.

  • The Platinum package include Wearable Sensing's DSI 24 System + NeuroGuide™ (NG) + NeuroGuide™ Collection module for the DSI (NC-DSI) + Choice of one of the following: LORETA Z-Score Neurofeedback (NF2) or BrainSurfer (Surfer). For Research Only. Save $1,295.00

  • Update Subscription expired?  Purchase an Update Subscription so you can download and install the latest releases of NeuroGuide software for 1 year.  Not sure if your Update Subscription has expired.. then Open NG click on Help and select License Information.  The Update Subscription Expiration date will be above the Customer ID or at the bottom of License Information window, depending on your current version on NeuroGuide.

  • Add the NeuroNavigator Diffusion Tensor Imaging (NNDTI) addon to view the DTI overlay(s) of the raw values or z-scores of the connectivity data of the NeuroNavigator. It is also possible to view the direction of the fibers in the NeuroNavigator, the Real-Time NeuroNavigator and the NeuroNavigator Time Domain Capture.  Must First Purchase NeuroNavigator (NN) and the swLORETA Current Source Density Normative Database (NNZ) and swLORETA Functional Connectivity Normative Database (NNF) and/or swLORETA Information Flow Normative Database (NNI) add-ons to NeuroGuide™ to use NNDTI.

  • Add Effective Connectivity to your NeuroGuide NeuroNavigator, Real-Time NeuroNavigator and the NeuroNavigator Time Domain Capture to view the Raw and Z Scores of Information Flow (Phase Slope Index) when you purchase the swLORETA Effective Connectivity Normative Database (Birth to 82 years). Must first purchase the NeuroNavigator (NN) and the swLORETA Current Density Normative Database (NNZ) add-ons to NeuroGuide™.

  • Add Functional Connectivity to your NeuroGuide NeuroNavigator, Real-Time NeuroNavigator and the NeuroNavigator Time Domain Capture to view the Raw Scores and/or Z Scores of Coherence, Lagged Coherence and Phase Difference by purchasing the swLORETA Functional Connectivity Normative Database (2 month - 82 years). Must first purchase NeuroNavigator and the swLORETA Current Source Density Normative Database (NNZ) add-on to NeuroGuide™.

  • Add Current Source Density Z Scores to your  NeuroGuide™ NeuroNavigator when you purchase the swLORETA Current Source Density Normative Database (2 months to 82 years).   One must first purchase the NeuroNavigator add-on to NeuroGuide™.

  • Concussion Index™ Uses

    $350.00$1,500.00

    Before purchasing a package Concussion Index™ uses, please verify that you have NeuroGuide™ Deluxe (Basic) v 2.9.1 or greater installed on your computer.

  • Brain Optimization Index Uses

    $350.00$1,500.00

    Use the Brain Optimization Index™ to track changes in a patient's various brain networks. The BOI can also be generated within an Automatic Clinic Report, if you purchase ACR uses. Before purchasing a Brain Optimization Index™ package, please verify that you have NeuroGuide v 3.0.7 or greater installed on your computer. NOTE if you have NeuroGuide v 2.9.3 - v 3.0.6 installed on your computer you can still purchase packages but the outputs will be labeled Brain Function Index and not include the latest updates.

  • We provide a competent and professional analysed qEEG Report by Robert W. Thatcher, Ph.D. for qEEG assessment and EEG biofeedback protocol generation. Dr. Thatcher has evaluated over 20,000 EEG recordings in the last 30 years. We provide an analysis of a recorded QEEG only and no diagnoses.

  • This Symptom Checklist (SCL) was developed with the goal of linking symptoms to areas of the brain. Set the Z Score cut off, Sort by Z Score or Name, then Save a Tab-delimited-Text file and/or Print the results.

  • 2, 4 & 19 Channel Instantaneous Z Score EEG Biofeedback. In 2004 Applied Neuroscience, Inc. invented Z score EEG biofeedback. The 1st real-time or "live" Z score controlling biofeedback was distributed as a dynamic link library (DLL) to companies in 2004. Agreements were formed with companies that already had existing scalp surface EEG Biofeedback products using raw EEG data. These companies wanted to use their software environment to add Z scores based on the raw values computed in about 1 microsecond or in real-time for 2, 4 and 19 channels.

  • LORETA Coherence and Phase Differences were computed by using cross-spectral analysis of Hilbert transforms of the current sources from the center voxels of each of 44 Brodmann areas in the left and right hemisphere in eight different frequency bands.

  • The LORETA Source Correlation Add-on computes the Pearson Product Correlation Coefficient (-1 to +1) with respect to a 3-dimensional Region of Interest (ROI) and the remainder of the 2,394 LORETA Gray Matter Pixels over the time span of selected EEG and then displays the results in the LORETA Viewer. The ROI is identified by either an Anatomical Name or by Brodmann Area. The average current sources of the ROI are used in the computation of the correlation coefficient and the ROI correlation to itself = 0 in the LORETA Viewer.

  • The LORETA Current Density normative database used the Key Institute's 'T' matrix and cross-spectrum equations to compute the cross-spectrum of the EEG from each subject in the NeuroGuide™ normative database for each 2,394 gray matter pixel. The NeuroGuide™ software was tested by comparisons to the Key Institute software programs. After log10 transforms of the Key Institute current density values, the means and standard deviations of the 2,394 LORETA currents were computed for different age groups from birth to 82 years thus enabling a Z score to be computed for each of the 2,394 gray matter pixels and displayed using the Key Institute's LORETA viewer.

  • sLORETA Z Score Neurofeedback: Z Score sLORETA biofeedback of Brodmann areas in the brain, “Hubs”, “Modules” and “Default Mode Network” and 3-dimensional locations registered to a reference MRI. Includes ‘Live’ sLORETA Coherence & Phase Differences from 88 Brodmann areas.

  • Surface 1 to 19 Channel Z Score Neurofeedback includes Average Reference, Linked Ears and Laplacian real-time Z scores. 'Live' or Real-time, coherence, phase difference, power, amplitude asymmetry, phase shift and phase lock duration Z scores. Includes a Symptom Check List and Surface EEG Z Scores to help structure a biofeedback protocol design. LORETA Z scores measured during a QEEG analysis are also used to further aid in the development of a neurofeedback protocol.

  • NeuroBatch

    $700.00

    Automatic Processing of Large Numbers of EEG Files. Group comparative statistics require the use of NeuroBatch™ to produce a NeuroGuide™ Group Analysis File or *.NGG file. Descriptive Group statistics include Means and Standard Deviations and independent t-tests between Groups (does not assume equal variance or sample sizes). Group statistics are used to compare different groups of subjects such as 100 ADD children to 100 normal children, etc.  Use NeuroBatch™ to create the *.NGG files before using NeuroStat™.

  • NeuroStat

    $700.00

    An EEG statistics program for test-retest and group analyses. It only takes a few mouse clicks to publish your results! Individual comparison options are independent t-tests, paired t-tests, and repeated measures analysis of variance (ANOVA) as well as absolute and percent differences for Surface EEG as well as LORETA.

    Descriptive Group statistics include Means and Standard Deviations and independent t-tests between Groups (does not assume equal variance or sample sizes).  Some group comparative statistics require the use of NeuroBatch™ to produce a NeuroGuide™ Group Analysis File.

  • The Brain Performance Index (BPI) is an estimate of the efficiency of neural resource allocation and it is not designed to replace a neuropsychological test but rather to compliment neuropsychological evaluations especially where a patient has problems taking a conventional neuropsychological test or when one wants to rapidly repeat the test.  Should only be used with clients between the ages of 5 and 18 years of old.

  • This powerful new state of the art 3-Dimensional Electrical Neuroimaging tool uses a real-MRI with 12,270 voxels; the Boundary Element Method (to compute the inverse solution to avoid the errors inherent in the use of a spherical head model, allowing for more accurate source localization at depths); and swLORETA (adjusts for source space inhomogeneity and provides accurate estimates of source gradients from the upper to the lower cortical layers). The NeuroNavigator with Raw Current Density values must be purchased before you can have access to the Real-Time NeuroNavigator and the NeuroNavigator Time Domain Capture Tools in NeuroGuide or before purchasing any of the NeuroNavigator add-on options. (See Description Tab).

  • View 3-Dimensional NeuroImaging of Functional Brain Networks,  sLORETA of Brodmann Areas & sLORETA of Networks, Z scores of nodes and connections between nodes as measured by sLORETA Coherence and sLORETA Phase Differences.
  • The Connectivity Suite is currently available is cortical connectivity from 171 electrode combinations in a single display. Use the latest techniques to analyze coherence, phase differences, correlation, cross-spectrum, co-spectrum, quad-spectrum, bi-spectrum and phase reset.

  • The Bi-Spectral analyses includes: Spectrum of the Time Series of Instantaneous Power; Spectrum of the Time Series Relative Power; Spectrum of the Time Series of Instantaneous Coherence; Spectrum of the Time Series of Instantaneous Phase Differences; Spectrum of the Time Series of Instantaneous Amplitude Differences; Spectrum of the Time Series of Phase Reset; and Cross-Frequency Power Correlation (1Hz to 50 Hz).

  • Seamlessly collect and analyze EEG Data using the NeuroGuide™ Collection Module. NeuroGuide™ can acquire EEG from the Zeto WR19, Deymed EEG32, CGX, Mitsar, NeuroField Q20 & Q21, NeXus Q32 & 32/32F, Medicom, NeuroSpectrum (2, 3, 4, 4EP, 4P & 5, 5S), BrainAmp, BrainMaster Discovery, ANT eegosports, BioSignal, Neuroelectrics (Enobio & Starstim), Contec, DeMeTec Data Box 30, ABM B-Alert X24*, Fistar,  ScienceBeam eWave, Wearable Sensing and NeuroPulse/Mindset and use the same amplifier(s) for Neurofeedback. The cost is $600 for each amplifier type. * See Description for Restrictions.

  • Learning Disabilities (LD) and mild Traumatic Brain Injury (TBI) discriminant functions.*

  • NeuroGuide

    $3,395.00

    The most affordable and comprehensive Conventional EEG & qEEG System Available. One can add Dynamic EEG Databases, LORETA, Discriminants, Power, Coherence, Phase, JTFA, Burst Metrics, Statistics, Instantaneous Coherence & Phase, Phase Lock & Phase Shift Duration, Batch Processing, Bi-Spectra & Neurofeedback options.

  • The Expert Mentoring/Consultation services available for Customers and Students that are provided by our ANI Staff  includes: Review of Patient EEG Data, Expert Training on NeuroGuide, Training on How to Create Clinical Reports, Special Data Analyses, Advanced Topics.  Personal Mentoring Session are provided via TeamViewer or Skype. The Fee is $250/hour

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